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Histol Histopathol. 2000 Jul;15(3):947-55. doi: 10.14670/HH-15.947.

The SH2 and SH3 adapter Nck: a two-gene family and a linker between tyrosine kinases and multiple signaling networks.

Author information

1
The Department of Medicine and the Norris Cancer Center, The University of Southern California Medical School, Los Angeles 90033, USA. wli@hsc.usc.edu

Abstract

SH2 and SH3 adapter proteins connect cell surface tyrosine kinases to intracellular signaling networks. For instance, the SH3-SH2-SH3 adapter Grb2 links receptor tyrosine kinases to the Ras pathway. Nck, composed of three SH3 domains and one SH2 domain, represents a two-gene (alpha and beta) family in mammals. Nckalpha and Nckbeta are expressed in the same cells and appear to have distinct signaling specificity. Studies show that Nck plays a role in cell mitogenesis and morphogenesis. The former uses Ras-dependent and Ras-independent pathways. The latter appears to coordinate with the Cdc42/Rac>PAK1/WASp>actin cytoskeleton pathway. Understanding the specificity of Nckalpha and Nckbeta signal transduction will provide answers for the previously often conflicting observations.

PMID:
10963137
DOI:
10.14670/HH-15.947
[Indexed for MEDLINE]

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