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Mech Dev. 2000 Sep;96(2):215-8.

Pattern of expression of the transcription factor Krox-20 in mouse hair follicle.

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Laboratoire de Différenciation Epithéliale, Ecole Normale Supérieure, 46, Rue d'Ulm, 75230, Cedex 05, Paris, France.


We examined the pattern of expression in hair follicles of the transcription factor gene Krox-20. During embryogenesis, Krox-20 is first expressed in the upper portion of the hair bud, then in the hair canal, in the sebaceous glands and in the outer root sheath. In the mature follicles, Krox-20, like Shh and TGFbetaRII, is also expressed in a sub-population of matrix keratinocytes located in a ring-like fashion in vibrissal follicles and clustered on one side of the papilla in pelage follicles. This polarized pattern rotates around the papilla as a result of sequential gene expression by individual groups of matrix cells. This peculiar pattern is not linked to follicle angling.

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