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Mech Dev. 2000 Sep;96(2):215-8.

Pattern of expression of the transcription factor Krox-20 in mouse hair follicle.

Author information

1
Laboratoire de Différenciation Epithéliale, Ecole Normale Supérieure, 46, Rue d'Ulm, 75230, Cedex 05, Paris, France.

Abstract

We examined the pattern of expression in hair follicles of the transcription factor gene Krox-20. During embryogenesis, Krox-20 is first expressed in the upper portion of the hair bud, then in the hair canal, in the sebaceous glands and in the outer root sheath. In the mature follicles, Krox-20, like Shh and TGFbetaRII, is also expressed in a sub-population of matrix keratinocytes located in a ring-like fashion in vibrissal follicles and clustered on one side of the papilla in pelage follicles. This polarized pattern rotates around the papilla as a result of sequential gene expression by individual groups of matrix cells. This peculiar pattern is not linked to follicle angling.

PMID:
10960786
DOI:
10.1016/s0925-4773(00)00398-1
[Indexed for MEDLINE]
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