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Cancer Lett. 2000 Oct 1;158(2):179-84.

Correlation of telomere lengths in normal and cancers tissue in the large bowel.

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Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, 32-5, Sakaecho Itabashi-ku, 173-0015, Tokyo, Japan.


The hypothesis that telomeres in colorectal cancer cells exhibit age-related shortening, as in normal cells of the colorectal epithelium, was tested with samples of non-cancerous mucosa and cancer tissue from 124 patients (aged 29-97 years). Shortening with aging could be demonstrated for both normal and cancer tissues; regression analysis showed rates for length reduction of 44 and 50 base pair/year, respectively. Straight, essentially parallel, lines were obtained for the two cases, normal tissue values being about 2 kilobase pairs (kbp) higher, with a significant correlation between data at the individual patient level.

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