Format

Send to

Choose Destination
See comment in PubMed Commons below
Biol Psychiatry. 2000 Aug 15;48(4):327-9.

Tryptophan depletion and risk of depression relapse: a prospective study of tryptophan depletion as a potential predictor of depressive episodes.

Author information

  • 1Department of Psychiatry, College of Medicine, The University of Arizona Health Sciences Center, Tucson 85724, USA.

Abstract

BACKGROUND:

This study investigated the relationship between depressive symptom response during tryptophan depletion and future depressive episodes.

METHODS:

Twelve subjects with prior major depressive episodes in remission and medication-free for > or =3 months (patients), and 12 matched healthy (control) subjects received two tryptophan depletion tests 1 week apart. During follow-up the Hamilton Depression Rating Scale was administered weekly for 1 month, monthly for 3 months, and once at 6 and 12 months.

RESULTS:

With results from both tests, tryptophan depletion has a sensitivity of 78%, specificity of 80%, positive predictive value of 70%, and negative predictive value of 86% to identify future depressive episodes. Survival analysis shows that mood response to tryptophan depletion reliably predicts major depressive episodes during the follow-up year (r =.2725, p =.014).

CONCLUSIONS:

Tryptophan depletion may be clinically useful in identifying individuals at risk for future major depressive episodes.

PMID:
10960166
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center