Format

Send to

Choose Destination
Invest New Drugs. 2000 Aug;18(3):205-20.

Development of multidrug-resistance convertors: sense or nonsense?

Author information

1
Department of Medical Oncology, Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital, The Netherlands. zuylen@onch.azr.nl

Abstract

This review describes the clinical relevance of the two drug transporters P-glycoprotein (Pgp) and multidrug resistance-associated protein (MRP) and the in vitro phenomenon which is referred to as multidrug resistance (MDR). The attempts to try to block these resistance mechanisms are summarized with specific attention for the intentionally designed "second generation" MDR-convertors. Potential explanations of the limited clinical success rate are given and recommendations for the design of future studies provided.

PMID:
10958589
DOI:
10.1023/a:1006487003814
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center