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J Neuropsychiatry Clin Neurosci. 2000 Summer;12(3):395-7.

Agitated symptom response to divalproex following acute brain injury.

Author information

1
Department of Brain Injury Rehabilitation,Good Shepherd Rehabilitation Hospital, Allentown, PA 18103-3296, USA.

Abstract

This is the largest case series (N=29) to date describing divalproex for agitation symptoms. Chart information was abstracted retrospectively for all patients who received divalproex for agitation symptoms during a 22-month period in one inpatient brain injury rehabilitation unit. For 26 patients (90%), divalproex appeared effective within 7 days after a typical 1,250 mg/day dose. Most patients (93%) were discharged to their home or community sites. Divalproex appears to be an efficacious alternative to neuroleptics and benzodiazepines for alert, labile, impulsive, and disinhibited brain injury patients.

PMID:
10956575
DOI:
10.1176/jnp.12.3.395
[Indexed for MEDLINE]

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