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Microbes Infect. 2000 Jun;2(7):793-801.

Signaling and invasin-promoted uptake via integrin receptors.

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  • 1Howard Hughes Medical Institute, Tufts University School of Medicine, Boston, MA 02111, USA.


The invasin protein encoded by enteropathogenic Yersinia allows entry of bacteria into intestinal M cells by binding to integrin receptors. In cultured cells, invasin-mediated uptake requires proteins involved in endocytosis and signaling to the cell cytoskeleton. At least four different factors have been demonstrated to play a role in regulating the efficiency of invasin-promoted uptake. These include receptor-ligand affinity, receptor clustering, signaling through focal adhesion kinase, and stimulation of cytoskeletal rearrangements by small GTP binding proteins.

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