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Pediatr Nephrol. 2000 Aug;14(8-9):856-8.

Chronic renal failure and portal hypertension--is portosystemic shunt indicated?

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  • 1Department of Multidisciplinary Pediatrics, La Timone Children's Hospital, Marseille, France.


We report two girls with histories of recessive polycystic kidney disease. Both were on maintenance hemodialysis. They had undergone surgical distal portocaval shunt because of portal hypertension. Later, bilateral nephrectomy was performed, and they presented with hepatic encephalopathy (HE) and evolution towards irreversible hepatic coma and death. Portosystemic shunt is the treatment of choice of portal hypertension. The kidney plays a pivotal role in ammonia disposal during portosystemic shunt. Thus, we stress the risk of HE after portosystemic shunt followed by bilateral nephrectomy in patients with end-stage renal failure and suggest that combined liver-kidney transplantation should be considered.

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