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Ross Fiziol Zh Im I M Sechenova. 2000 Jun;86(6):671-80.

[Genetic aspects of arterial hypertension: the role of Y chromosome and mitochondrial DNA].

[Article in Russian]

Author information

1
Moscow State University, Russia.

Abstract

A study on hybrids from reciprocal crossing of the SHR-SP and the WKY has shown that Y-chromosome and mitochondrial DNA the affect development of the spontaneous hypertension. The Y-chromosome takes part in disorders of baroreceptive sensitivity in phenylnephrine assay associated with hypertension. Although our findings suggest that structural remodelling of peripheral vascular resistance and an increase in noradrenaline-dependent vasocostriction is genetically determined in hypertensive rats, we could not corroborate the role of the Y-chromosome and mitochondrial DNA in the process. A difference was shown between male and female SHR-SP in the level of arterial pressure and in development of the vascular structure changes.

PMID:
10955304
[Indexed for MEDLINE]

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