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Immunol Today. 2000 Sep;21(9):455-64.

Antigen-processing machinery breakdown and tumor growth.

Author information

1
Johannes Gutenberg-University, III. Dept of Internal Medicine, Langenbeckstr. 1, 55131 Mainz, Germany. B.Seliger@3-med.klinik.uni-mainz.de

Abstract

Defects in the major histocompatibility complex (MHC) class I antigen-processing machinery (APM) have been described in tumors of different histology. Murine data suggest that defects in the MHC class II APM might also be associated with malignant transformation of human cells. This article describes the pathophysiology of the MHC class I and II APM, reviews APM abnormalities in tumor cells and discusses their role in the escape of tumor cells from in vitro recognition by T cells.

PMID:
10953098
DOI:
10.1016/s0167-5699(00)01692-3
[Indexed for MEDLINE]

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