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Immunol Today. 2000 Sep;21(9):436-41.

Dissecting affinity maturation: a model explaining selection of antibody-forming cells and memory B cells in the germinal centre.

Author information

1
The Walter and Eliza Hall Institute for Medical Research, PO Royal Melbourne Hospital, Victoria 3050, Australia. tarlinton@wehi.edu.au

Abstract

Until recently, the relationship between apoptosis, selection in the germinal centre (GC) and production of high-affinity antibody-forming cells (AFCs) and memory B cells has been unclear. Here, Tarlinton and Smith present a model that accounts for the switch in GC production from high-affinity AFCs to memory B cells, and explain how Bcl-2, an inhibitor of apoptosis, can influence memory cells but not bone marrow AFCs.

PMID:
10953095
DOI:
10.1016/s0167-5699(00)01687-x
[Indexed for MEDLINE]

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