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Transgenic Res. 2000 Apr;9(2):145-54.

Role of the melanocortin-4 receptor in metabolic rate and food intake in mice.

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1
Department of Metabolic Disorders, Merck Research Laboratories, NJ, USA.

Abstract

We evaluated the role of the melanocortin-4 receptor (MC-4R) in the control of metabolic rate and food intake in mice. Intraperitoneal administration of the non-selective MC-R agonist melanotan II (MT-II; a cyclic heptapeptide) increases metabolic rate in wildtype mice, while MC-4R knockout mice are insensitive to the effects of MT-II on metabolic rate. MC-4R knockout mice are also insensitive to the effects of MT-II on reducing food intake. We conclude that MC-4R can mediate control of both metabolic rate and food intake in mice. We infer that a role for MC-3R in mediating the acute effects of MT-II on basal metabolic rate and food intake in wildtype mice seems limited.

PMID:
10951699
[Indexed for MEDLINE]
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