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Int J Obes Relat Metab Disord. 2000 Aug;24(8):976-81.

Relative hypoleptinemia in patients with type 1 and type 2 diabetes mellitus.

Author information

1
Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna, Vienna, Austria. michael.roden@akh-wien.ac.at

Abstract

OBJECTIVE:

To determine the relation between plasma leptin concentrations and metabolic control in human diabetes mellitus.

DESIGN AND SUBJECTS:

Cross sectional study consisting of 156 patients with diabetes mellitus type 1 (n=42), type 2 (n=114), and non-diabetic subjects (n=74).

RESULTS:

Plasma leptin concentrations were lower (P<0.05) in type 1 (8.3+/-1.7 ng/ml) and type 2 diabetic (14.9+/-1.8 ng/ml) than in non-diabetic humans (18.3+/-1.9 ng/ml). Only female type 1 and type 2 diabetic subjects also had decreased leptin/BMI ratios (P<0.05 vs non-diabetic females). The log rank test identified age-adjusted correlation of plasma leptin concentration with sex (P<0.0004) and body mass index (P<0.0218), but not with glycosylated haemoglobin A1c (P>0.5) in all groups. Plasma leptin was correlated with age (P<0.0058) and serum triglycerides (P<0.0199) in type 1 diabetic patients, and with serum cholesterol (P<0.0059) and LDL (P<0.0013) in type 2 diabetic patients.

CONCLUSIONS:

Defective leptin production and/or secretion might be present independently of metabolic control in female patients with type 1 or type 2 diabetes mellitus.

PMID:
10951535
[Indexed for MEDLINE]

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