Send to

Choose Destination
See comment in PubMed Commons below
J Gen Virol. 2000 Sep;81(Pt 9):2215-8.

Activation of cellular interferon-responsive genes after infection of human cells with herpes simplex virus type 1.

Author information

Medical Research Council Virology Unit, Church Street, Glasgow G11 5JR, UK.


Previous studies have shown that infection of human fibroblasts with human cytomegalovirus (HCMV) results in activation of cellular interferon-responsive gene expression. We demonstrate here that infection of human fibroblasts with herpes simplex virus type 1 (HSV-1) in the absence of de novo protein synthesis also induces the expression of interferon-responsive genes. Five genes tested (encoding ISG54, IFI56, ISG15, 9-27 and MxA) were activated by infection with HSV-1, although the degree of response varied between the individual genes. HSV-1 was a less efficient inducer than HCMV. The effect was a consequence of binding of the virus particle to the cell surface or of the presence of virion components within the infected cell. Induction was mediated by a pathway other than the mechanism through which interferon-alpha mediates its effects on cellular gene expression.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons


    Supplemental Content

    Full text links

    Icon for Ingenta plc
    Loading ...
    Support Center