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Hematol Oncol Clin North Am. 2000 Aug;14(4):745-60, vii.

A brief history of the randomized controlled trial. From oranges and lemons to the gold standard.

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Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.


This article discusses the history and development of randomized clinical trial methodology, the reasons for its status and authority as a method of therapeutic evaluation, and the continuing role of clinical judgement in designing, interpreting, and applying the findings of trials.

[Indexed for MEDLINE]

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