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Int J Tuberc Lung Dis. 2000 Aug;4(8):784-7.

Effect of combined therapy of oral anti-tubercular agents on theophylline pharmacokinetics.

Author information

1
Department of Pharmacy, Woosuk University, South Korea.

Abstract

To evaluate the effects of combined therapy of anti-tubercular agents with theophylline during treatment of concurrent pulmonary tuberculosis and chronic obstructive pulmonary disease or asthma, the clearance and half life of theophylline was estimated in a control group not treated with anti-tubercular agents, a group treated with isoniazid (INH), rifampicin (RMP), ethambutol (EMB) and pyrazinamide (PZA), and a group treated with INH, RMP and EMB. Clearances of theophylline in the treated groups were significantly lower than in the control group, and the half-life of theophylline was longer than in the control. These results suggest that patients administered combinations of anti-tubercular agents with theophylline require lower doses of theophylline.

PMID:
10949332
[Indexed for MEDLINE]

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