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Transplantation. 2000 Aug 15;70(3):541-3.

Pediatric utilization of rapamycin for severe cardiac allograft rejection.

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1
Department of Cardiology, The Hospital for Sick Children, University of Toronto, Canada.

Abstract

BACKGROUND:

Rapamycin is a new immunosuppressive agent that has been shown to be effective in the treatment of acute cardiac rejection in the adult population.

METHODS:

This case documents a pediatric patient with ongoing cardiac rejection that did not abate despite treatment with antithymocyte serum (RATS), corticosteroid pulses, and methotrexate in addition to daily prednisone, mycophenolate mofetil, and tacrolimus.

RESULTS:

Initiation of therapy with rapamycin resulted in a rapid resolution of cardiac rejection and reduction of concomitant immunosuppressive agents and few side effects.

CONCLUSIONS:

This case illustrated the utilization of rapamycin in a pediatric patient with ongoing acute rejection despite several modifications in treatment.

PMID:
10949201
[Indexed for MEDLINE]
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