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Mutat Res. 2000 Aug 30;460(3-4):319-32.

The BRCA1 C-terminal domain: structure and function.

Author information

1
Molecular Structure and Function, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, WC2A 3PX, London, UK.

Abstract

The BRCA1 C-terminal region contains a duplicated globular domain termed BRCT that is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions with DNA strand breaks. The sequence and functional diversity of the BRCT superfamily suggests that BRCT domains are evolutionarily convenient interaction modules.

PMID:
10946236
DOI:
10.1016/s0921-8777(00)00034-3
[Indexed for MEDLINE]

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