Format

Send to

Choose Destination
See comment in PubMed Commons below
Br J Psychiatry. 2000 Jul;177:15-9.

Factor structure and familiality of first-rank symptoms in sibling pairs with schizophrenia and schizoaffective disorder.

Author information

1
Prince of Wales Centre, University Department of Psychiatry, Warneford Hospital, Oxford.

Abstract

BACKGROUND:

Since their introduction as diagnostic criteria by Schneider in 1937, nuclear symptoms have played a key role in concepts of schizophrenia, but their relationship to each other and to genetic predisposition has been unclear.

AIMS:

To ascertain the factor structure and familiality of nuclear symptoms.

METHODS:

Nuclear (Schneiderian) symptoms were extracted from case notes and interviews in a study of 103 sibling pairs with DSM-III-R schizophrenia or schizoaffective disorder.

RESULTS:

Principal components analysis demonstrated two major factors: one, accounting for about 50% of the variance, groups thought withdrawal, insertion and broadcasting, with delusions of control; and the second, accounting for < 20% of the variance, groups together third-person voices, thought echo and running commentary. Factor I was significantly correlated within sibling pairs.

CONCLUSIONS:

The correlation within sibling pairs suggests that, contrary to the conclusion of some previous studies, some nuclear symptoms do show a degree of familiality and therefore perhaps heritability.

PMID:
10945082
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center