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Exp Nephrol. 2000 Jul-Oct;8(4-5):208-14.

Polycystin expression in the kidney and other tissues: complexity, consensus and controversy.

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MRC Molecular Haematology Unit, Institute of Molecular Medicine, University of Oxford, Headington, Oxon.,


PKD1, the major gene mutated in autosomal dominant polycystic kidney disease, was identified in 1994, and fully sequenced in 1995. The protein which it encodes, polycystin-1, is the first member of a new family of proteins, whose functions presently remain unclear. This review seeks to highlight the difficulties researchers studying polycystin-1 have faced and to summarize the current areas of consensus and controversy between different groups, particularly with regard to the expression pattern, subcellular location and biochemical characterization of polycystin-1. Where relevant, more recent data regarding polycystin-2, the protein encoded by PKD2, will also be discussed.

[Indexed for MEDLINE]

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