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Exp Nephrol. 2000 Jul-Oct;8(4-5):208-14.

Polycystin expression in the kidney and other tissues: complexity, consensus and controversy.

Author information

1
MRC Molecular Haematology Unit, Institute of Molecular Medicine, University of Oxford, Headington, Oxon., UK.a.ong@sheffield.ac.uk

Abstract

PKD1, the major gene mutated in autosomal dominant polycystic kidney disease, was identified in 1994, and fully sequenced in 1995. The protein which it encodes, polycystin-1, is the first member of a new family of proteins, whose functions presently remain unclear. This review seeks to highlight the difficulties researchers studying polycystin-1 have faced and to summarize the current areas of consensus and controversy between different groups, particularly with regard to the expression pattern, subcellular location and biochemical characterization of polycystin-1. Where relevant, more recent data regarding polycystin-2, the protein encoded by PKD2, will also be discussed.

PMID:
10940718
DOI:
10.1159/000020670
[Indexed for MEDLINE]

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