A PET study of adenosine A1 receptor in anesthetized monkey brain

Nucl Med Biol. 2000 May;27(4):401-6. doi: 10.1016/s0969-8051(00)00089-5.

Abstract

We demonstrated the distribution of adenosine A1 receptors in the anesthetized monkey brain with positron emission tomography (PET) using [(11)C]KF15372 ([1-propyl-(11)C]8-dicyclopropylmethyl-1, 3-dipropylxanthine). [(11)C]KF15372 was injected intravenously. The regional standardized uptake values and the distribution volume were calculated. We also investigated the effect of carrier on the uptake and regional brain distribution of [(11)C]KF15372. The use of [(11)C]KF15372 with dynamic PET scanning could be an appropriate method to analyze the regional binding potential of adenosine A1 receptors in living brain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anesthesia
  • Animals
  • Brain Chemistry*
  • Carbon Radioisotopes*
  • Cerebrovascular Circulation
  • Female
  • Macaca fascicularis
  • Receptors, Purinergic P1 / analysis*
  • Tomography, Emission-Computed*
  • Xanthines / metabolism*

Substances

  • Carbon Radioisotopes
  • Receptors, Purinergic P1
  • Xanthines
  • 8-(dicyclopropylmethyl)-1,3-dipropylxanthine