Format

Send to

Choose Destination
See comment in PubMed Commons below
Int J Oncol. 2000 Sep;17(3):439-44.

Ancestrally-duplicated paraHOX gene clusters in humans.

Author information

1
Laboratoire d'Oncologie Moleculaire, U.119 Inserm, Institut Paoli-Calmettes, Marseille, France.

Abstract

A paraHox gene cluster has been described recently in Amphioxus. We show here using bioinformatics and cytogenetics that, as the probable result of the duplication of an ancestral paraHox gene cluster, human paraHOX genes are located in four paralogous regions of the genome, on chromosomes 4, 5, 13 and X. By analogy with the four HOX gene clusters, we propose to designate the four paraHOX gene clusters as paraHOX-A to D clusters. We also propose a scenario for the evolution of HOX and paraHOX genes. Several chromosomal translocation breakpoints of hemopathies are located in the paralogous regions that contain the paraHOX genes. Two of the paraHOX genes are involved in these rearrangements.

PMID:
10938381
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Spandidos Publications
    Loading ...
    Support Center