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Bioorg Med Chem Lett. 2000 Aug 7;10(15):1729-31.

Synthesis and evaluation of quinoxalinones as HIV-1 reverse transcriptase inhibitors.

Author information

1
DuPont Pharmaceuticals Company, Experimental Station, Wilmington, DE 19880-0500, USA. mona.patel@dupontpharma.com

Abstract

A series of 3,3-disubstituted quinoxalinones was prepared and evaluated as HIV-1 reverse transcriptase inhibitors. The N-allyl (6b and 6f), N-cyclopropylmethyl (6a, 6g, 6h, and 6k) and N-carboalkoxy (6m-6y) substituted compounds displayed activity comparable or better than Efavirenz and GW420867X.

PMID:
10937734
DOI:
10.1016/s0960-894x(00)00321-8
[Indexed for MEDLINE]

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