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Behav Genet. 2000 Jan;30(1):77-81.

Inheritance of pendulum movements in rats.

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  • 1Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.


The stereotyped hyperkinesis referred to as pendulum movements (PM) may be found in up to 50% of the animals in stocks of Wistar rats. The mode of inheritance of predisposition to PM was studied by two methods: 1) a classical Mendelian analysis of hybrids of the strains PM+ and PM- bred from Wistar stock for enhancement and absence of PM, respectively, and 2) a segregation analysis of pedigree data from the archive records of breeding the cataleptic GC strain. The two methods gave the same result: the inheritance of predisposition to PM can be explained by a major gene model with an incomplete penetrance of heterozygous genotype.

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