Format

Send to

Choose Destination
Immunity. 2000 Jul;13(1):95-105.

The CD28-related molecule ICOS is required for effective T cell-dependent immune responses.

Author information

1
Department of Biology, Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts 02139, USA. coyle@mpi.com

Abstract

While CD28 is critical for expansion of naive T cells, recent evidence suggests that the activation of effector T cells is largely independent of CD28/B7. We suggest that ICOS, the third member of the CD28/CTLA-4 family, plays an important role in production of IL-2, IL-4, IL-5, and IFNgamma from recently activated T cells and contributes to T cell-dependent B help in vivo. Inhibition of ICOS attenuates lung mucosal inflammation induced by Th2 but not Th1 effector populations. Our data indicate a critical function for the third member of the CD28 family in T cell-dependent immune responses.

PMID:
10933398
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center