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Nat Struct Biol. 2000 Aug;7(8):617-9.

Intimate details of the most poisonous poison.

Abstract

Crystal structures of type B botulinum neurotoxin, determined under conditions relevant to the extracellular binding and intracellular substrate cleavage steps of its toxic action, reveal that minimal structural changes occur upon binding a ganglioside or after substrate cleavage. The unique structure of this toxin provides information for developing preventive measures against botulism.

PMID:
10932240
DOI:
10.1038/77900
[Indexed for MEDLINE]

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