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Nat Med. 2000 Aug;6(8):849-51.

Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology.

Author information

1
Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9039, USA.

Abstract

Cells from the telomerase knockout mouse immortalize with an approximately ten million-fold greater frequency than human cells. In this commentary, Wright and Shay discuss the implications of this difference between mice and men and its relationship to cancer.

PMID:
10932210
DOI:
10.1038/78592
[Indexed for MEDLINE]

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