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Nat Genet. 2000 Aug;25(4):376-7.

The NOTCH4 locus is associated with susceptibility to schizophrenia.

Author information

  • 1Institute of Biological Psychiatry, Schizophrenia Association of Great Britain, Bryn Hyfryd, The Crescent, Bangor, Gwynedd, UK. jwei@hgmp.mrc.ac.uk

Abstract

Linkage disequilibrium mapping of the MHC region in 80 British parent-offspring trios showed that NOTCH4 was highly associated with schizophrenia. The A-->G substitution in the promoter region and the (CTG)n repeat in exon 1 of NOTCH4 may be candidate sites conferring susceptibility to schizophrenia.

PMID:
10932176
DOI:
10.1038/78044
[PubMed - indexed for MEDLINE]
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