Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Cell Biol. 2000 Sep;10(9):362-5.

Fibroblast-collagen-matrix contraction: growth-factor signalling and mechanical loading.

Author information

1
Dept of Cell Biology, UT Southwestern Medical School, Dallas, TX 75235-9039, USA. frederick.grinnell@email.swmed.edu

Abstract

Fibroblast-collagen-matrix contraction provides a unique way to study reciprocal geometric and mechanical interactions between fibroblasts and extracellular matrix. Such interactions are difficult to appreciate or examine in routine cell culture because the culture surface is usually fixed in place. Forces exerted on collagen fibrils by cells cause isometric tension to develop in the cells if the collagen resists deformation; by contrast, the cells remain mechanically unloaded in the absence of matrix resistance. Recent evidence suggests that the state of cellular mechanical loading determines the mechanism that cells use to regulate contraction.

PMID:
10932093
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center