Format

Send to

Choose Destination
Magn Reson Imaging. 2000 Jul;18(6):689-95.

Effects of cell volume fraction changes on apparent diffusion in human cells.

Author information

1
Department of Diagnostic Radiology, PO Box 208042, Yale University School of Medicine, New Haven, CT 06520-8042, USA. adam.anderson@yale.edu

Abstract

Diffusion-weighted imaging was used to study the relationship between apparent diffusion coefficient (ADC) and cell volume fraction in cell suspensions and packed arrays. Cell volume fraction was varied by changing extracellular fluid osmolarity (for human glial cells) and by changing cell density (for human glial and red blood cells). In packed arrays of glial cells, ADC increased 10% when cells shrank and decreased 13% when cells swelled. ADC decreased 34% as cell density increased from 0 to 72%. In erythrocyte suspensions, ADC decreased 90% as the cell density increased from 0 to 89%. These results agree with theoretical predictions.

PMID:
10930778
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center