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Ann Intern Med. 2000 Aug 15;133(4):280-4.

Effect of antiretroviral therapy on HIV shedding in semen.

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1
Laboratório de Pesquisas, Hospital Universitário Clementino Fraga Filho, School of Medicine, Universidade Federal do Rio de Janeiro, Brazil.

Abstract

BACKGROUND:

The effect of antiretroviral therapy on seminal HIV shedding in the community remains unknown.

OBJECTIVE:

To evaluate the effect of antiretroviral therapy on HIV shedding in semen.

DESIGN:

Prospective cohort study.

SETTING:

University hospital in Rio de Janeiro, Brazil.

PATIENTS:

93 HIV-infected men.

INTERVENTION:

Antiretroviral therapy as prescribed by each patient's physician.

MEASUREMENT:

HIV RNA in semen and blood plasma before and after introduction of therapy.

RESULTS:

At baseline, HIV RNA was detected in 69 semen samples (74%) and 89 blood samples (96%). Six months after introduction of therapy, HIV RNA was detected in 29 semen samples (33%) and 33 blood samples (38%). The mean reduction in levels of HIV RNA in semen at 6 months was 1.65 log10 units.

CONCLUSIONS:

Antiretroviral therapy reduces shedding of HIV in semen, which probably in tum reduces HIV transmissibility. However, a substantial proportion of patients may still be infectious and may have drug-resistant strains of the virus.

PMID:
10929169
[Indexed for MEDLINE]
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