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Anticancer Res. 2000 May-Jun;20(3B):2009-13.

Prognostic significance of matrix metalloproteinases 2 and 9 in bladder cancer.

Author information

1
Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, Athens, Greece.

Abstract

BACKGROUND:

The levels of matrix metalloproteinases MMP-2 and MMP-9 (type IV collagenases), which degrade the extracellular matrix of the basement membrane, were evaluated as prognostic indicators of metastasis in urothelial carcinoma.

MATERIALS AND METHODS:

Quantitative gel zymography and immunohistochemistry were used and compared with clinical data at the follow-up period of 36 months.

RESULTS:

Zymographical analysis of the levels of MMP-9 and active MMP-2 showed a statistically significant increase with tumor grade and invasiveness. This correlation was confirmed by immunohistochemical analysis of MMP-9 expression. However, the correlation between the levels of both gelatinases with recurrence in superficial tumours or progression in invasive tumours was not statistically significant.

CONCLUSION:

MMPs may have an important role in the invasion mechanism of urothelial cancer and could be useful prognostic markers for patients with bladder carcinoma. The relationship between MMP-2 and MMP-9 expression and the metastatic potential of bladder carcinoma needs further evaluation in subsequent clinical studies.

PMID:
10928143
[Indexed for MEDLINE]

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