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Free Radic Biol Med. 2000 May 15;28(10):1478-86.

Biological chemistry and clinical potential of S-nitrosothiols.

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Biophysics Research Institute, Medical College of Wisconsin, Milwaukee, WI 53226, USA.


S-Nitrosothiols are endogenous metabolites of nitric oxide that have been detected in extra- and intracellular spaces. Many biological functions of S-nitrosothiols have been described that can be categorized as being due to one or more of the following: (i) nitric oxide release, (ii) transnitrosation, (iii) S-thiolation, and (iv) direct action. This emphasizes the fact that S-nitrosothiols are more than simply nitric oxide donors. Many of the biological functions that have been described for S-nitrosothiols have clinical correlates. This review describes the biological chemistry, biological actions, and clinical potential of these compounds.

[Indexed for MEDLINE]

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