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Fertil Steril. 2000 Aug;74(2):261-7.

Hormone replacement therapy reverses the decrease in natural killer cytotoxicity but does not reverse the decreases in the T-cell subpopulation or interferon-gamma production in postmenopausal women.

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  • 1Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.

Abstract

OBJECTIVE:

To investigate the immunologic deviations of postmenopausal women before and after hormone replacement therapy (HRT).

DESIGN:

Prospective study.

SETTING:

University teaching hospital.

PATIENT(S):

Seventeen postmenopausal women (study group) and 17 women of reproductive age (control group).

INTERVENTION(S):

Continuous usage of E(2) valerate 2 mg/d and medroxyprogesterone acetate 5 mg/d in postmenopausal women in the study group.

MAIN OUTCOME MEASURE(S):

Immunophenotyping with flow cytometry, cytokine production with and without mitogen stimulation of the peripheral mononuclear cells, and a natural killer (NK) cell cytotoxicity test against K562 target cells by the (51)Cr-release assay were performed in the control group and in the study group before, 1 month after, and 6 months after HRT.

RESULT(S):

NK cytotoxicity, interferon-gamma production, and the T-cell subpopulation were significantly decreased, and the subpopulations of CD3(+)CD25(+) and CD3(+)HLA-DR(+) were increased in the study group before HRT when compared with those in the control group. After HRT was given for 6 months, however, the NK cytotoxicity increased significantly in the postmenopausal women to a value similar to that of the control group.

CONCLUSION(S):

Women after menopause are prone to impaired immune responses. Nevertheless, some of the impairment can be restored after HRT.

PMID:
10927042
[PubMed - indexed for MEDLINE]
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