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Brain Res Mol Brain Res. 2000 Jun 23;79(1-2):156-8.

IL-1beta induced changes in hypothalamic IL-1R1 and IL-1R2 mRNA expression in the rat.

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School of Biological Sciences, The University of Manchester, UK.


Interleukin-1 receptor (IL-1R1 and IL-1R2) mRNA expression was detected within the rat hypothalamus, a primary site of IL-1 action, using RT-PCR. Levels of expression were unchanged by cardiac saline-perfusion. However, intracerebroventricular (i.c.v.) administration of IL-1beta caused changes in receptor mRNA expression in non-perfused animals that were profoundly different to those observed in their saline-perfused counterparts. This study demonstrates the importance of perfusing tissue to remove blood cells when determining changes in IL-1 receptor mRNA expression.

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