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Zhonghua Yi Xue Za Zhi. 1998 May;78(5):340-2.

[Hepatitis B virus infection and aflatoxin exposure in the development of primary liver cancer].

[Article in Chinese]

Author information

1
Qidong Liver Cancer Institute, Jiangsu.

Abstract

OBJECTIVE:

To investigate the role of hepatitis B Virus (HBV) infection and aflatoxin (AF) exposure in the development of primary liver cancer (PLC).

METHODS:

A 10-year prospective case-control study was carried out in 737 HBsAg carriers and 699 HBsAg negative cases, and the aflatoxin B1 albumin adducts (AFB1-Alb) were detected in the serum of the cohort including 30 HBsAg postive cases and 150 control individuals according to the case-control study model (ratio 1:5) at random in the high prevalance area of PLC.

RESULTS:

The average year-incidence rate was significantly higher in the HBsAg postive group (824.13/100,000) than in the control group (70.97/100,000, RR = 11.61). There was no significant difference in the incidence rate of other tumors between the two groups (P > 0.05). The serum positive rate of AFB1-Alb was significantly higher in the PLC group (76.67%) than in the control group (48.67%, OR = 3.47), and the serum concentration of AFB1-Alb was also significantly higher in the PLC group than in the control group (P < 0.01).

CONCLUSION:

HBV infection and AF exposure are important etiological factors in the development of PLC and both result in carcinogenic synergy.

PMID:
10923435
[Indexed for MEDLINE]

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