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Trends Microbiol. 2000 Aug;8(8):376-83.

Selective nuclear export of viral mRNAs in influenza-virus-infected cells.

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Institute for Cellular and Molecular Biology, Section of Molecular Genetics and Microbiology, The University of Texas at Austin, 2500 Speedway, Austin, TX 78712, USA.


The NS1A protein of influenza A virus specifically inhibits the cellular machinery that processes the 3' ends of cellular pre-mRNAs by targeting two of the essential proteins of this machinery. Because the virus does not use this cellular machinery to synthesize the 3' poly(A) ends of viral mRNA, the nuclear export of cellular but not viral mRNAs is selectively inhibited.

[Indexed for MEDLINE]

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