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Trends Endocrinol Metab. 2000 Sep;11(7):276-80.

Steroid regulation of postembryonic development and reproduction in Drosophila.

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Howard Hughes Medical Institute, 15 N 2030 E Rm 5100, University of Utah, UT 84112-5331, USA.

Erratum in

  • Trends Endocrinol Metab 2000 Dec;11(10):436.


Ecdysteroids trigger major developmental transitions in Drosophila, including larval molts and metamorphosis. Recent genetic studies strongly support a role for the Ecdysteroid receptor (EcR)/Ultraspiracle (USP) heterodimer as an ecdysteroid receptor at the onset of metamorphosis, functioning as both a transcriptional activator and repressor in vivo. Genetic analysis also indicates that USP, like its vertebrate homolog retinoid X receptor (RXR), might be involved in regulatory pathways independently of EcR. The ecdysteroid hierarchy was also shown recently to regulate Drosophila oogenesis and reproduction.

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