Format

Send to

Choose Destination
See comment in PubMed Commons below
Am J Obstet Gynecol. 2000 Jul;183(1):136-9.

The relationship of smoking, preeclampsia, and secretory component.

Author information

1
Department of Obstetrics and Gynaecology, National Women's Hospital, School of Medicine, University of Auckland, New Zealand.

Abstract

OBJECTIVE:

We sought to determine whether total secretory component in serum is increased in women in whom preeclampsia subsequently develops.

STUDY DESIGN:

Serum samples were collected serially throughout pregnancy and post partum from nulliparous women (N = 1496). Serum concentrations of total secretory component were measured by an enzyme-linked immunosorbent assay in all women in whom preeclampsia developed (n = 71) and a randomly selected group of normotensive women (n = 83).

RESULTS:

Secretory component increased with smoking (P =.0003) and with gestation (P =.0001). In the whole group secretory component was not different in women with preeclampsia (P =.10), but there was a significant interaction of smoking, gravidity, and preeclampsia (P =.04). Among the women who smoked, secretory component was lower in women in whom preeclampsia subsequently developed compared with those who remained normotensive (P =.02). This difference was significant from 15 to 19 weeks' gestation.

CONCLUSION:

Very high serum concentrations of secretory component in smokers may protect against the development of preeclampsia and may indicate the involvement of mucosal tolerance.

PMID:
10920321
DOI:
10.1067/mob.2000.105745
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center