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Am J Clin Nutr. 2000 Aug;72(2):476-83.

Intake of antioxidant vitamins and risk of death from stroke in postmenopausal women.

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1
Intergroup of Arizona, Phoenix, and the Division of Epidemiology, the University of Minnesota, Minneapolis 55454, USA.

Abstract

BACKGROUND:

Antioxidant vitamins may play a role in the prevention of stroke because they scavenge free radicals and prevent LDL oxidation. Epidemiologic studies that have examined this relation produced conflicting results.

OBJECTIVE:

We examined the association between antioxidant vitamin intakes and death from stroke.

DESIGN:

This was a prospective cohort study of 34492 postmenopausal women.

RESULTS:

During follow-up, 215 deaths from stroke were documented. Total vitamin A, carotenoid, and vitamin E intakes were not associated with death from stroke after multivariate adjustment. Relative risks (RRs) and 95% CIs of the highest compared with the lowest category were 0.79 (0.45, 1.38; P for trend = 0.33) for vitamin A, 0.80 (0.45, 1.40; P for trend = 0.40) for carotenoids, and 0.91 (0.55, 1.52; P for trend = 0.86) for vitamin E. The test for trend for total vitamin C intake was significant, although the association appeared somewhat U-shaped, not monotonic. An inverse association was seen between death from stroke and vitamin E intake from food. RRs (and 95% CIs) of death from stroke from the lowest to highest intake categories were 1.0, 0.80 (0.51, 1.26), 0.93 (0.58, 1. 49), 0.67 (0.39, 1.14), 0.40 (0.20, 0.80); P for trend = 0.008. The results suggest inverse associations between death from stroke and intakes of the most concentrated vitamin E food sources consumed by this cohort: mayonnaise, nuts, and margarine.

CONCLUSIONS:

Our results suggest a protective effect of vitamin E from foods on death from stroke but do not support a protective role for supplemental vitamin E or other antioxidant vitamins. However, given the number of deaths from stroke in the present cohort, a small-to-moderate association could not be ruled out.

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PMID:
10919944
[Indexed for MEDLINE]
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