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Arzneimittelforschung. 2000 Jun;50(6):564-8.

Synthesis and activity of new acylated diaminohydroxyalkanes as human immunodeficiency virus protease inhibitors.

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1
Department of Pharmaceutical Sciences, University of Ferrara, Italy.

Abstract

A series of HIV-1 protease inhibitors based on the lead compound Pc (IC50 = 165 nmol/l) with structural modifications at P1/P1' substituents or with a lengthening at its core unit were synthesized from amino acid starting materials. All analogues were less active than Pc against the protease.

PMID:
10918952
DOI:
10.1055/s-0031-1300250
[Indexed for MEDLINE]
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