Development. p73--guilt by association?

Science. 2000 Jul 14;289(5477):257-8. doi: 10.1126/science.289.5477.257.

Abstract

It has been assumed that the new members of the p53 protein family, p63 and p73, would have the same job as p53, namely, forcing cells to die if they or their DNA is damaged. Now, as Morrison and Kinoshita explain in their Perspective, one particular form of p73 has been found to be a survival factor rather than a death factor for sympathetic neurons during development (Pozniak et al.).

Publication types

  • Comment

MeSH terms

  • Animals
  • Apoptosis
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology*
  • Genes, Tumor Suppressor
  • Mice
  • Neurons / physiology*
  • Nuclear Proteins / genetics
  • Nuclear Proteins / physiology*
  • Sympathetic Nervous System / cytology
  • Sympathetic Nervous System / growth & development*
  • Sympathetic Nervous System / physiology
  • Tumor Protein p73
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / physiology
  • Tumor Suppressor Proteins

Substances

  • DNA-Binding Proteins
  • Nuclear Proteins
  • Trp73 protein, mouse
  • Tumor Protein p73
  • Tumor Suppressor Protein p53
  • Tumor Suppressor Proteins