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Science. 2000 Jun 30;288(5475):2299-300.

Obesity. Enzyme blocker prompts mice to shed weight.

Abstract

A multidisciplinary team may have discovered an important new weapon in the battle of the bulge. On page 2379 of this issue, the team reports that a molecule that is needed for fat synthesis in the body may play a key role in appetite signaling in the brain. Moreover, the investigators produced a synthetic inhibitor of this molecule that spurred a dramatic drop in appetite and weight in mice.

PMID:
10917820
[Indexed for MEDLINE]

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