Abstract
A multidisciplinary team may have discovered an important new weapon in the battle of the bulge. On page 2379 of this issue, the team reports that a molecule that is needed for fat synthesis in the body may play a key role in appetite signaling in the brain. Moreover, the investigators produced a synthetic inhibitor of this molecule that spurred a dramatic drop in appetite and weight in mice.
MeSH terms
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Animals
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Appetite / drug effects
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Appetite Depressants / pharmacology*
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Brain / metabolism
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Enzyme Inhibitors / pharmacology*
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Fasting
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Fatty Acid Synthases / antagonists & inhibitors*
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Humans
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Liver / drug effects
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Liver / metabolism
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Malonyl Coenzyme A / metabolism
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Mice
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Neuropeptide Y / genetics
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Neuropeptide Y / metabolism
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Obesity / drug therapy*
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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Weight Loss / drug effects*
Substances
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Appetite Depressants
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Enzyme Inhibitors
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Neuropeptide Y
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RNA, Messenger
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Malonyl Coenzyme A
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Fatty Acid Synthases