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Trends Biochem Sci. 2000 Aug;25(8):352-6.

Maturation of cellular Fe-S proteins: an essential function of mitochondria.

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Institut für Zytobiologie und Zytopathologie der Philipps-Universität Marburg, Robert-Koch-Str. 5, 35033 Marburg, Germany.


Iron-sulfur (Fe-S) cluster-containing proteins perform important tasks in catalysis, electron transfer and regulation of gene expression. In eukaryotes, mitochondria are the primary site of cluster formation of most Fe-S proteins. Assembly of the Fe-S clusters is mediated by the iron-sulphate cluster assembly (ISC) machinery consisting of some ten proteins.

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