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Mutat Res. 2000 Jun 30;451(1-2):151-67.

Mismatch repair proteins and mitotic genome stability.

Author information

1
Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA 30322, USA.

Abstract

Mismatch repair (MMR) proteins play a critical role in maintaining the mitotic stability of eukaryotic genomes. MMR proteins repair errors made during DNA replication and in their absence, mutations accumulate at elevated rates. In addition, MMR proteins inhibit recombination between non-identical DNA sequences, and hence prevent genome rearrangements resulting from interactions between repetitive elements. This review provides an overview of the anti-mutator and anti-recombination functions of MMR proteins in the yeast Saccharomyces cerevisiae.

PMID:
10915870
DOI:
10.1016/s0027-5107(00)00047-6
[Indexed for MEDLINE]

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