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Bioorg Med Chem Lett. 2000 Jul 17;10(14):1519-22.

Synthesis and in vitro evaluation of human FP-receptor selective prostaglandin analogues.

Author information

1
Procter & Gamble Pharmaceuticals, Mason, OH 45040, USA. delong.ma@pg.com

Abstract

The in vitro evaluation of a series of saturated prostaglandins revealed that compounds with omega chain aromatic rings retain nanomolar potency for the human prostaglandin F receptor (hFP receptor), exemplified by compound 8. In contrast, the double bonds are required for activity in the series with an acyclic omega chain as in PGF2alpha.

PMID:
10915040
DOI:
10.1016/s0960-894x(00)00273-0
[Indexed for MEDLINE]

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