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Biochem Biophys Res Commun. 2000 Aug 2;274(2):496-9.

Membrane permeability modifications are involved in antibiotic resistance in Klebsiella pneumoniae.

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Faculté de Médecine, CJF 9606 INSERM, Université de la Méditerranée, 27 Boulevard Jean Moulin, Marseille Cedex 05, 13385, France.


Two Klebsiella pneumoniae strains selected according to their high cross-resistance pattern to cephalosporins were characterized by (i) outer membrane protein content such as OmpA or nonspecific porins, (ii) MICs of various cephalosporins and unrelated antibiotics, (iii) beta-lactamase production, and (iv) active efflux of fluoroquinolones. An association of porin deficiency and beta-lactamase production induced a noticeable cephalosporin resistance. In addition to these mechanisms, the presence of an active efflux participating in high-level fluoroquinolone resistance was identified in one strain. The decrease of antibiotic uptake associated with efflux explains the Klebsiella adaptation against the drugs present in the environment.

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