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Mol Cell Biol. 2000 Aug;20(16):5840-6.

Aldose reductase-deficient mice develop nephrogenic diabetes insipidus.

Author information

1
Institute of Molecular Biology, The University of Hong Kong, China.

Abstract

Aldose reductase (ALR2) is thought to be involved in the pathogenesis of various diseases associated with diabetes mellitus, such as cataract, retinopathy, neuropathy, and nephropathy. However, its physiological functions are not well understood. We developed mice deficient in this enzyme and found that they had no apparent developmental or reproductive abnormality except that they drank and urinated significantly more than their wild-type littermates. These ALR2-deficient mice exhibited a partially defective urine-concentrating ability, having a phenotype resembling that of nephrogenic diabetes insipidus.

PMID:
10913167
PMCID:
PMC86061
DOI:
10.1128/mcb.20.16.5840-5846.2000
[Indexed for MEDLINE]
Free PMC Article

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