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Ann N Y Acad Sci. 2000;909:145-58.

GABA modulation of cocaine self-administration.

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Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1083, USA.


Recent experiments suggest that GABA compounds produce a clinically relevant modulation of cocaine reinforcement. This review summarizes the results of a number of studies that examined the effect of the GABAB agonist baclofen on cocaine self-administration using a variety of schedules of reinforcement. The results demonstrate that baclofen causes a dramatic reduction in cocaine self-administration which does not appear to be accounted for by a general disruption of behavior. However, the effect is dependent on the unit injection dose of cocaine and on the response requirements of the schedule. These results predict that in a clinical setting any potential therapeutic effect of baclofen will interact with the cost and availability of cocaine.

[Indexed for MEDLINE]

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